20 September 2017
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  Dr Ali Nokhodchi
 
Dr Ali Nokhodchi: 
Head of Pharmaceutical Technology Laboratory

Associate professor and head of postgraduate studies

Tel: 0098 411 360884

Fax: 0098 411 3344798

E-mail: nokhodchi@tbzmed.ac.ir

Dr Nokhodchi's Home Page


Curriculum Vitae:
Dr Ali Nokhodchi is associate professor of Pharmaceutical Technology and head of postgraduate studies in school of Pharmacy in Tabriz University of Medical Sciences.  He also is the head of Pharmaceutical Technology Laboratory in Drug Applied Research Center.  He graduated in Pharm. D. from Tabriz University of Medical Sciences-Iran in 1988 and received his PhD from Liverpool John Moores University-UK in 1996.  His PhD research project covered The Compaction Properties of Hydroxypropylmethylcellulose 2208 and Ibuprofen.  He has got training in Pharmaceutical Company (Squibb Pharm. company Tehran-Iran) in 1988-1989.

Dr Nokhodchi currently teaches Pharmaceutical technology (for pharmacy undergrduate and postgraduaie students), Pharmaceutics (for pharmacy undergrduate and postgraduaie students), Hygienic and cosmetics (for pharmacy undergrduate and postgraduaie students), Practical pharmaceutical technology (for postgraduate students) and Practical hygienic and cosmetics (for Postgraduate students).

Dr Nokhodchi is a member of Iranian Association of Pharmaceutical Scientists.  He is also editor of the Journal of Pharmaceutical Sciences of the Pharmacy School of Tabriz University of Medical Sciences.

Current research programs:

1.  Formulation of sustained release matrices and chemical stability studies

2.  Microencapsulation

3.  Skin absorption studies especially the effects of surfactants and terpene enhancers

4.  Solid dispersions of poorly soluble drugs

5.  Cosolvency studies

6.  Habit modification and characterisation of pharmaceutical powders

7.  Bioavailability/bioequivalency studies (mainly as consultancy for pharmaceutical companies)

8.  Formulation of hygienic and cosmetic products

9.  Physics of Compaction and compression of Pharmaceutical powders

Research experiences in addition to the Pharm D and PhD thesis are listed bellow:

1. Research fellowship for Colorcon, Ltd, Kent, UK (full time, July 1996- February 1997)

2. Working (part time) as a research consultant for IND management (USA) carried out in the School of Pharmacy, Liverpool John Moores University ( for a period of 6 months in 1993)

3. Consultancy for Colorcon, Ltd, Kent, UK, carried out in the School of Pharmacy and Chemistry, Liverpool John   Moores University (for a period of 6 months in 1995)

4. Consultancy for IND management on oral Insulin (for a period of 6 months in 1996)

5. Supervision of 5 PhD students (since 1997)

6- Supervison of more than 35 PharmD. projects

 Publications in international journals:

1.  N. Bolourtchian, A. Nokhodchi, R. Dinarvand . The effect of solvent and crystallization on habit modification of carbamazepine. DAROU 2001; 9, 12-22.

2.  A. Nokhodchi, M. H. Rubinstein . An overview on the compaction and compression properties of HPMC and ethylcellulose. STP Pharm Sci. 2001;11, 195-202. 

3.  J. Shokri, A. Nokhodchi, D. Hassan-Zadeh, A. Dashbolaghi, T. Ghafourian. Effects of surfactant on the skin penetration of diazepam. Int. J. Pharm.2001; 228, 99-107. 

4.  Mohammadi Samani, Massoud Adrangui, Djavad Farid and Ali Nokhodchi. An approache into controlled-release dosage formes of propranolol hydrochloride. Drug Dev. Ind. Pharm. 2000; 26, 91-94. 

5.  J. Akbari, M. Adrangui, J. Farid, M.R. Siahi-Shadbad and  A. Nokhodchi. Factors affecting the release rate of a poorly soluble drug (carbamazepine) from HPMC matrices. STP Pharma Sci. 2000; 10, 473-478. 

6.  Mohammadi Samani, Massoud Adrangui, Djavad Farid and Ali Nokhodchi. Effects of polysorbates on the atenolol releases from film coated tablets. Drug Dev. Ind. Pharm. 1999; 25 (4) 513-516. 

7.  Ali Nokhodchi, Noushin Bolourtchian and Djavad Farid. Effects of hydrophilic excipients and compression pressure on the physical properties and release behaviour of aspirin tableted microcapsules. Drug Dev. Ind. Pharm. 1999; 25, 711-716. 

8.  A.R. Rajabi-Siahboomi and Ali Nokhodchi. The compression properties of methyl- and hydroxypropylmethyl- cellulose polymers. Pharm. Sci. Cumm.1999; 5, 67-71. 

9.  Ali Nokhodchi, P. Khaseh, T. Ghafourian, M.R. Siahi-Shadbad. The role of various surfactants in controlling release rate of theophylline from HPMC matrices. STP Pharma. Sci.1999; 9, 555-560. 

10.  Dj. Farid, M. Hassani and Ali Nokhodchi. Sustained release formulation of nifedipine.Indian J. Pharm. Sci.1998; 60 (6) 375-378. 

11.  Ali Nokhodchi and Michael H. Rubinstein. The compaction properties of HPMC-ibuprofen mixtures compacts. S.T.P. Pharma Sci.1998; 8/6 , 343-348. 

12.  Ali Nokhodchi and Michael H. Rubinstein. The effect of moisture content on the compaction properties of ibuprofen-HPMC mixture. S.T.P. Pharma Sci.1998; 8/6, 349-356. 

13.  Ali Rajabi-Siahboomi, Ali Nokhodchi, M. H. Rubinstein. The compaction behaviour of hydrophilic cellulose ether polymers. Pharm. Technol., Tableting Year Book,1998; 42-48. 

14.  Ali Nokhodchi, Djavad Farid, Moslem Najafi and Massoud Adrangui. Studies on controlled release formulations of diclofenac sodium. Drug Dev. Ind. Pharm.1997;  23, 1019-1023. 

15.  Ali Nokhodchi, James L. Ford, Michael H. Rubinstein. Studies on the interaction between water and hydroxypropylmethylcellulose. J. Pharm. Sci.1997; 86, 608-615. 

16.  Ali Nokhodchi, James L. Ford, Pillip Rowe and Michael H. Rubinstein. The effects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropylmethylcellulose.  Int. J. Pharm.1996; 129, 21-31. 

17.  Ali Nokhodchi, James L. Ford, Pillip Rowe and Michael H. Rubinstein. The influence of moisture content on the consolidation properties of hydroxypropylmethylcellulose K4M (HPMC 2208) J. Pharm. Pharmacol.1996; 48, 1116-1121. 

18.  Ali Nokhodchi, James L. Ford, Pillip Rowe and Michael H. Rubinstein. The effect of moisture on the Heckel and energy anlysis of hydroxypropylmethylcellulose 2208. J. Pharm. Pharmacol.1996; 48, 1122-1127. 

19.  Ali Nokhodchi and Michael H. Rubinstein.  Compaction Simulators in tabletting research.  Pharmaceutical Technology,  Tabletting and granulation year book.1996; 6,8,10,12,16,18,67. 

20.  Ali Nokhodchi, Michael H. Rubinstein, Hassan Larhrib, Jean C. Gyout. The effect of moisture on the properties of ibuprofen tablets. Int. J. Pharm.1995; 118, 191-197. 

21.  Ali Nokhodchi, Michael H. Rubinstein, Hassan Larhrib, Jean C. Gyout. The effect of moisture content on the energies involved in the compaction of ibuprofen. Int. J. Pharm.1995; 120, 13-20. 

22.  Ali Nokhodchi, James L. Ford and Michael H. Rubinstein. The effect of particle size and viscosity grade on the compaction properties of K grade of hydroxypropylmethylcellulose. Int. J. Pharm.1995; 126, 189-197. 

23.  Ali Nokhodchi, Michael H. Rubinstein and James L Ford. The effects of viscosity grade of hydroxypropylmethylcellulose (HPMC) on its compaction properties J. Pharm. Pharmacol.1994; 46, 1075.

 24.  Ali Nokhodchi and Djavad Farid. Effect of various factors on microencapsulation of acetyl salicylic acid by a non-solvent addition method. S.T.P. Pharma Sci.1992; 2, 279-283.

 25.  Ali Nokhodchi and Djavad Farid. Dissolution of compacted aspirin microcapsules. Indian J. Pharm. Sci.1991; 53, 222-223.

26.  A. Nokhodchi, S. Norouzi-Sani, M.R. Siahi-Shadbad, F. Lotfipoor, and M. Saeedi.  The effect of various surfactants on the release rate of propranolol hydrochloride from HPMC-Eudragit matrices. Eur. J. Pharm. Biopharm.  2002; 54, 349-356.

27.  A. Nokhodchi, H. Nazemieh, T. Ghafourian, D. Hassan-Zadeh, H. Valizadeh, and L.A.S. Bahry.  The effect of glycerrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations.Il Farmaco. 2002; 57, 883-888.

28.  S. Azarmi, J. Farid, A. Nokhodchi, H. Valizadeh, and B. Saravi.  Termal Treating as a tool for a sustained release of indomethacine from Eudragit RS and RL 100.  Int. J. Pharm. 2002; October, 171-177.

29. A. Nokhodhi, P. Zakeri-Milani, H. Valizadeh, and D. Hassan-Zadeh.  Prediction of solubility of benzodiazepines using different cosolvency models. Il Famaco. 2002; 57, 555-557.

30.  A. Nokhodchi, and J. Farid.  Microencapsulation of paracetamol by various emulsion techniques using cellulose acetate phthalate. Tech. 2002; June, 54-60.

31.  A. Nokhodchi, et al.  Evaluation of microcapsules of ASA prepared with CAP, EC or their mixture by non-solvent addition technique. Ars Pharmaceutica. 2002; 43, 135-145.

32.  A. Nokhodchi, N. Bolourchian, and R. Dinarvand.  Crystal modification of phenytoin using different solvents and crystallization condition.  Int. J. Pharm. 2003; 250, 85-97.

33.  A. Nokhodchi, J. Shokri, A. Dashbolaghi, D. Hassan-Zadeh, T. Ghafourian, and M. Barzegar-Jalali.  The enhancement effect of surfactants on the penetration of lorazpam through rat skin.  Int. J. Pharm. 2003; (in press)

 Presentations (oral and posters) in international conferences:

1.  R. Dinarvand, N. Bolourtchian, A. Nokhodchi. Modification of phenytoin crystal habit using various crystallization methods. world congress of pharmacy and pharmaceutical sciences, 2001; Singapore.

 2.  N. Bolourtchian, A. Nokhodchi, R. Dinarvand. Crystal habit modification and polymorphism of carbamazepine: The effect of crystallization condition. World congress of pharmacy and pharmaceutical sciences, 2001; Singapore.

 3.  A. Nokhodchi, J. Shokri, D. Hassan-Zadeh, T. Ghafourian, M. Barzegar-Jalali. Prediction of benzodiazepine solubility using different cosolvency models. 3rd Pharmaceutical Chemistry Symposium, 2001;Turkey, Istanbul.

 4.  M. saeeidi, K. Mortaza-Semnani, J. Farid, A. Nokhodchi, J. Akbari. Relationship between the rate constant  of the Higuchi equation and polymer content in buccal-adhesive tablets of propranolol hydrochloride. 20th Pharmaceutical Technology Conference, 2001; Liverpool, UK.

 5.  A. Nokhodchi, S. Norouzi-Sani, M.R. Siahi-Shadbad, M. Saeeidi. The role of binary mixtures of surfactant in controlling the release rate of propranolol from HPMC matrices. PAC/FAPA Conference, 2000; Sydney, Australia.

 6.  A. Nokhodchi, P. Zakeri-Milani, H. Valizadeh, D. Hassan-Zadeh. Evaluation of polymers in microencapsulation of ASA. 19th International Pharmaceutical Conference, 2000; April, Baveno, Italy.

 7.  A. Nokhodchi, P. Khaseh, T. Ghafourian, M.R. Siahi-Shadbad. The role of various surfactants in controlling the release rate of theophylline from HPMC matrices. 3rd World Meetting on Biopharmaceutics and Pharmaceutical Technology, 2000; April, Berlin, Germany.

 8.  A. Nokhodchi, H. Nazemeah, T. Ghafourian, D. Hassan-Zadeh, L. S. Bahari. Glycyrrhizin as novel human skin penetration enhancer. 10th Int. Pharm, Tech., 2000; September, Istanbul, Turkey.

 9.  J. Akbari, Dj. Farid, M. Adrangui, A. Nokhodchi, M.R. Siahi-Shadbad, M. Saeedi. Factors affecting the release of carbamazepine from HPMC matrices. 18th International Pharmaceutical Technology, 1999; Uttricht (Netherland).

 10.  M. saeedi, Dj. Farid, M. Adrangui, A. Nokhodchi,   M.R. Siahi-Shadbad and J. Akbari. The effects of fillerson the release rate of propranolol hydrochloride from buccal-adhesive tablets. 18th International Pharmaceutical Technology, 1999; Uttricht (Netherland).

 11.  Mohammadi Samani, Masoud Adrangui, Djavad Farid and Ali Nokhodchi. Effect of polysorbates on the atenolol releases from film coated tablets. 17th Int. Pharmaceutical Technology Conference, 1998; Dublin, Ireland.

 12.  Ali Nokhodchi, Ali R. Siahboomi, Mohsen Rahmani and Michael H. Rubinstein. The compaction properties of methocel derivatives. 2nd World Meetting on Biopharmaceutics and Pharmaceutical Technology, 1998; Paris, France.

 13.  Mohammadi Samani, Massoud Adrangui, Mohammad reza Siahi and Ali Nokhodchi. Propranolol oral osmotic pump. 2nd World Meetting on Biopharmaceutics and Pharmaceutical Technology. 1998; Paris, France.

14.  Dj. Farid, N. Bolourtchian and Ali Nokhodchi. Effect of hydrophilic excipients and compression pressure on physical properties and release behaviour of aspirin-tableted microcapsules. 133th British Pharmaceutical Conference. 1998; (UK).

15.  D. Hassan-zadeh, Ali Nokhodchi and M.S. Roberts. The effects of pH and polarity of electrode on the remaining propranolol within human skin. 133th British Pharmaceutical Conference.1998; (UK).

16.  Ali Nokhodchi, Michael H. Rubinstein. The compaction properties of HPMC-Ibuprofen compacts.16th Int. Pharmaceutical Technol. Conrefence in Athens-Greece;1997.

  17. Ali Nokhodchi, James L. Ford and Michael H. Rubinstein. The effect of particle size on the compaction properties of the K series of HPMC 2208. 14th Int. Pharm. Technol. in Barcelona-Spain;1995.

18.  Ali R. Siahboomi and Ali Nokhodchi. Effect of moisture on the swelling of HPMC tablets. 4th UKaps. Annual Conf. in Nottingham;1995.

19.  Djavad Farid, Massoud Adrangui, Mohammed H. Shahbazi and Ali Nokhodchi. Microencapsulation of paracetamol using cellulose acetate phthalate. 10th Int. Symposium on microencapsulation,1995; Texas-USA.

20.  Ali Nokhodchi, Michael H. Rubinstein, Hassan Larhrib, Jean C. Gyout. The effect of moisture on the compaction properties of Ibuprofen tablets. 13th Int. Pharm. Techno. in Strasbourg-France; 1994.

21.  Ali Nokhodchi, Michael H. Rubinstein, Hassan Larhrib, Jean C. Gyout. The effect of moisture content on the energies involved during the compaction of ibuprofen tablets. 13th Int. Pharm. Technol. in Strasbourg-France; 1994.

22.  Ali Nokhodchi, James L. Ford and Michael H. Rubinstein. The compaction properties of hydroxypropylmethycellulose 2208. 10th Compaction Simulator User Group Metting at Merck Sharp and Dohme (MSD); 1994.

23.  Ali Nokhodchi, Michael H. Rubinstein and James L. Ford. The effect of viscosity grade of hydroxypropylmethylcellulose 2208 on its compaction properties.  131th British Pharmaceutical Conference in London-UK; 1994.

24.  Ali Nokhodchi, Djavad Farid and Masoud Adrangui. Factors affecting drug release from compacted A.S.A. microcapsules and capsules prepared by non-solvent addition method. 8th Int. Symposium on microencapsulation, 1992; Dublin-Ireland.